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Inside Dentistry
June 2011
Volume 7, Issue 6

Treating Dentin Hypersensitivity

Unique tray system can be used in the office and at home.

While there are several different products currently available that are promoted to treat dentin hypersensitivity, REME•SENSE™ (dipotassium oxalate 3%) TOOTH DESENSITIZER is the only one offering a unique easy-to-use tray system and both in-office and prescription at-home convenience (Figure 1). The FDA recognizes dipotassium oxalate 3% as an effective treatment for the management of dentin hypersensitivity and there are validated clinical trials to support its use.1

REME•SENSE™ is a Class II Rx medical device that consists of a flexible tray and impregnated foam strips. When placed in the mouth, the active ingredient embedded in the foam matrix is released in a sustained and controlled manner. The patient experiences immediate relief after a 10-minute application that protects up to 1 month. Additionally, REME•SENSE™ offers the patient a pressure gradient that is much higher when compared to a solution or gel application, exceeding patient brushing or burnishing teeth with a rubber cup, and a non-abrasive therapy.1

Oxalates react with calcium ions in the mouth to form insoluble calcium-oxalate crystals that are deposited at the aperture of the dentin tubules. In a subject-blind, stratified, randomized clinical study more than 84% of patients experienced an important positive reduction after using REME•SENSE™.1 In a clinical analysis to determine the treatment and application time needed to reduce dentinal hypersensitivity, it was demonstrated that due to the mode of delivery and long contact time, REME•SENSE™ would have an effect on dental hypersensitivity that could last up to 4 weeks.1

The foam strips are placed on the ledges in the tray. The tray is then inserted into the mouth making sure it fits closely around the teeth and the lips are pulled over it. The notch on the tray border should face up. The patient should be instructed not to bite or press too hard on the tray to prevent the gel from being expressed from the impregnated foam matrix. It is recommended that the tray not be removed during treatment. If there is excessive saliva, aspire the patient's mouth or remove the tray, have the patient spit out, and then allow the patient to reinsert the tray for the remaining time. After 10 minutes, remove the tray from the mouth and discard. Instruct the patient not to eat, rinse, or brush their teeth for 30 minutes.

In an in vitro study conducted at Heinrich-Heine University in 2008, it was demonstrated by SEM photomicrographs that after REME•SENSE™ treatment, many crystal-like inclusions were seen at the surface of the dentin tubules (Figure 2 and Figure 3). Further, "those photographs show that the tubules are stuffed below the surface with crystals proving that the product penetrates deep into the dentine tubules... (Figure 4) A deeper precipitate provides a greater surface area for mechanical locking between the precipitate and dentinal tubules, which makes the precipitate difficult to remove from the dentinal tubules".2

REME•SENSE™ may cause eye irritation upon contact and is contraindicated in patients with a known allergy to any of its ingredients. The product is intended for dental use only. Patents are pending.


1. Data on File. Nuline Pharmaceuticals, LLC, Parsippany NJ; 2011.

2. Bizhang M. Effects of Desensitizing Agents on Dentine Tubule Hypersensitivity. Heinrich-Heine University; February 2008.

For more information, contact:

Nuline Pharmaceuticals

Phone: 877-NULINE1




The preceding material was provided by the manufacturer. The statements and opinions contained therein are solely those of the manufacturer and not of the editors, publisher, or the Editorial Board of Inside Dentistry.

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