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UB awarded $1.5 million to reprogram white blood cells in fight against oral cancer

Posted on March 26, 2021

The University at Buffalo has received a $1.5 million grant from the United States Department of Defense to develop new therapies that help reduce chronic inflammation and immunosuppression in oral cancers.

Through the three-year grant, the research will center on a type of white blood cell called a macrophage that – after migrating to oral tumors – triggers uncontrolled inflammation, which suppresses the body’s immune response and lowers the effectiveness of anticancer therapies.

The researchers aim to reprogram the macrophages by targeting genes that regulate inflammation. By lowering inflammation, oral cancers will become more sensitive to new and traditional chemotherapies.

If successful, the findings could help increase survivorship of oral cancers, which claim the life of roughly half of all oral cancer patients within five years, according to Keith Kirkwood, DDS, PhD, principal investigator, Centennial Endowed Chair and professor of oral biology in the UB School of Dental Medicine.

“A change in behavior in the white blood cells within the tumor itself removes the ‘brakes’ in the system, causing more oral cancer growth,” says Kirkwood, also associate dean for innovation and technology transfer in the UB School of Dental Medicine. “We propose to reprogram the white blood cells to regain control of the brakes.”

Additional investigators from Roswell Park Comprehensive Cancer Center include Wesley Hicks Jr., MD, DDS, chair of the Department of Head and Neck/Plastic and Reconstructive Surgery; William Magner, PhD, scientist in the Department of Immunology; and Scott Abrams, PhD, professor in the Department of Immunology.

The research will focus on oral squamous cell carcinoma, the most common type of oral cancer. Found in the lips, mouth or throat, oral cancers can affect the ability to eat and speak, and may cause permanent disfigurement of the face.

Veterans are two times more likely to develop head and neck cancers than non-veterans, says Kirkwood. The increased risk may be attributed to higher rates of alcohol and tobacco use among veterans, he says. Nearly 75% of oral cancers are caused by either alcohol or tobacco use, according to outside research. 







Align Technology’s Invisalign Brand Is the Official Smile Partner of US Ski & Snowboard

Posted on March 26, 2021

Align Technology, Inc, makers of the Invisalign® clear aligner system, today announced a partnership with US Ski & Snowboard, making the Invisalign brand the Official Smile of US Ski & Snowboard, the Olympic national governing body of ski and snowboard sports in the United States. The multi-year, worldwide sponsorship includes development of original Invisalign branded content across social media channels and for the US Ski & Snowboard website. As part of the agreement, US Ski & Snowboard will launch a program for athletes to join the Invisalign Smile Squad and receive Invisalign treatment and then share their Invisalign treatment experiences on their social media profiles.

“Smiles, skiing, and snowboarding go hand-in-hand, so we’re excited to connect with athletes from the US Ski, Snowboard, and Freeski teams and their fans around the world,” said Kamal Bhandal, Align Technology vice president, Global Brand and Consumer Marketing. “Our purpose is transforming smiles and changing lives, and we admire these talented and inspirational athletes and their commitment to being the best in the world. We look forward to working with US Ski & Snowboard athletes on the Invisalign Smile Squad and supporting their Invisalign treatment journeys as they come to life in their stories and experiences shared across media platforms.”

“We’re all smiles in announcing Align’s Technology’s Invisalign brand as our first-ever Official Smile Partner,” said Michael O’Conor, chief revenue officer for US Ski & Snowboard. “Smiling confidently is a feeling our athletes know well, whether on the slopes or the top of the podium. We are excited to partner with a brand committed to using technology to change lives for the better, just as we are committed to supporting our athletes in their pursuit of excellence. We look forward to sharing our Invisalign Smile Squad stories and introducing the Invisalign brand to our fans around the world.”

“We welcome US Snowboard Team athletes Jamie Anderson, Maddie Mastro, and Red Gerard, and US Freeski Team athlete David Wise to the Invisalign Smile Squad and are excited to support their Invisalign treatment journey as they join over 9.6 million patients around the world who have used the Invisalign system to improve their smiles,” said Frank Quinn, Align Technology vice president and general manager, US. “We’re proud to be the Official Smile of US Ski & Snowboard and to help Invisalign trained doctors transform the winning smiles of these great US athletes.”

At 30 years old, Jamie Anderson continues to raise the bar in women’s competitive snowboarding and beyond. Anderson is a double-Olympic gold medalist, earned silver in the inaugural 2018 Olympic big air, and is the winningest female X Games athlete of all time, with 19 medals. Most recently, Anderson has proven herself in the world of backcountry snowboarding, competing in events like the Natural Selection event and filming her own movie, Unconditional. Anderson is thrilled to partner with the Invisalign brand to bring her smile to the next level. “My smile is a reflection of my best self!” said Anderson. “I’m excited to partner with the Invisalign brand so I can give my smile that extra boost. Invisalign treatment will help elevate my confidence on and off the snow.”

Maddie Mastro was an Olympian at the age of 17 and has since medaled at two World Championships. She is the first woman to ever land the "double crippler" both in and out of halfpipe competition, putting her at the forefront of women’s snowboard progression. As an elite athlete always in the spotlight, Mastro is excited to partner with Invisalign in making her smile podium-ready. “I absolutely love my Invisalign treatment and am super excited to be a brand athlete ambassador!” Mastro said. “Invisalign clear aligners work great for an active lifestyle and you can’t even tell you are wearing them, which makes for a winning smile.”

Red Gerard became a household name at the 2018 Olympics where he became the youngest male US Olympian to win a gold in 90 years at the age of 17 with his win in snowboard slopestyle. Gerard went on to earn gold at the 2019 Burton US Open and bronze at X Games Aspen 2020. Gerard is more than a competition snowboarder; his film Joy won Movie of the Year at the 2020 Snowboarder Awards, and he's a star of the 2020 Burton team video "One World." “My partnership with the Invisalign brand is ideal due to my heavy travel schedule competing and filming all year,” said Gerard. “It’s a quick and simple program that allows me to focus on riding while it focuses on my teeth.” 

David Wise is a husband, father, and the only male freeski halfpipe gold medalist in Olympic history, winning the inaugural contest at the 2014 Sochi and 2018 PyeongChang Olympic Winter Games. Wise also has four X Games gold medals, 16 World Cup podiums, and a World Championship victory to his name. Invisalign clear aligners will provide a perfect solution to help Wise work on his smile while keeping up with his busy home and competitive life. “Looking your best helps give you that extra bit of confidence,” Wise said. “In my sport, confidence is everything. While I’ve always wanted a less crooked smile, I’ve been reluctant to use traditional orthodontics. I’m excited to begin Invisalign treatment because it fits my chaotic lifestyle and won’t make me hide my teeth along the way. I look forward to breaking out a new winning smile.”







April is Oral Cancer Awareness Month

Posted on March 26, 2021

Every hour, 24-hours-a-day, 365-days-a-year, someone dies of oral or oropharyngeal cancer (cancer of the mouth and upper throat). Yet, if oral cancer is detected and treated early, treatment-related health problems are reduced and survival rates may increase.

This year an estimated 54,0001 new cases of oral cancer will be diagnosed. Of those individuals, 43 percent will not survive longer than five years, and many who do survive suffer long-term problems, such as severe facial disfigurement or difficulties with eating and speaking. The death rate associated with oral and oropharyngeal cancers remains particularly high because the cancers routinely are discovered late in their development.

This April, as the nation observes the 22st Annual Oral Cancer Awareness Month, the Academy of General Dentistry Foundation (agd.org/agd-foundation), the American Academy of Oral and Maxillofacial Pathology (aaomp.org), American Academy of Oral and Maxillofacial Radiology (www.aaomr.org), the American Association of Oral and Maxillofacial Surgeons (myoms.org), the American Academy of Oral Medicine (aaom.com), the American Academy of Periodontology (perio.org), the American College of Prosthodontics (www.prosthodontics.org), the American Dental Hygienists' Association (www.adha.org), and the California Dental Hygienists' Association (www.cdha.org) are again joining the non-profit Oral Cancer Foundation in its campaign to raise awareness of oral cancer screenings and the importance of early detection.

Regular oral cancer examinations performed by your oral health professional remain the best method for detecting oral cancer in its early stages.

Be Mindful of Symptoms: Public Urged to "Check Your Mouth"

For the third straight year, the efforts of the Foundation and the dental associations cited above will be bolstered by the Oral Cancer Foundation's Check Your Mouth™ initiative (www.checkyourmouth.org). Check Your Mouth encourages the public to regularly check for signs and symptoms of oral cancer between dental visits, and to see a dental professional if they do not improve or disappear after two or three weeks.

Signs and symptoms of oral cancer which is predominantly caused by tobacco usage and/or excessive alcohol usage may include one or more of the following:

-Any sore or ulceration that does not heal within 14 days.

-A red, white, or black discoloration of the soft tissues of the mouth.

-Any abnormality that bleeds easily when touched (friable).

-A lump or hard spot in the tissue, usually border of the tongue (induration).

-Tissue raised above that which surrounds it; a growth (exophytic).

-A sore under a denture, which even after adjustment of the denture, that does not heal.

-A lump or thickening that develops in the mouth.

-A painless, firm, fixated lump felt on the outside of the neck, which has been there for at least two weeks.

-All the above symptoms have the commonality of being persistent and not resolving.

Signs and symptoms of HPV-caused oropharyngeal cancer may include one or more of the following (which may persist longer than two-three weeks):

-Hoarseness or sore throat that does not resolve within a few weeks.

-A swollen tonsil on just one side. This is usually painless.

-A painless, firm, fixated lump felt on the outside of the neck, which has been there for at least two weeks.

-A persistent cough that does not resolve after many days.

-Difficulty swallowing; a sensation that food is getting caught in your throat.

-An earache on one side (unilateral) that persists for more than a few days.

-All the above symptoms have the commonality of being persistent and not resolving.

-Always call your dentist right away if there are any immediate concerns.

Risk Factors

Research has identified a number of factors that may contribute to the development of oral and oropharyngeal cancers. Historically, those at an especially high risk of developing oral cancer have been heavy drinkers and smokers older than age 50, but today the cancer also is occurring more frequently in nonsmoking people due to HPV16, the virus most commonly associated with cervical cancer.

The sexually transmitted human papillomavirus 16 (HPV) is related to the increasing incidence of oropharyngeal cancer (most commonly involving lymphoid tissue occurring in the tonsils or the base of the tongue). Approximately 99 percent of people who develop an HPV oral infection will clear the virus on their own. In approximately 1 percent of individuals the immune system will not clear the virus and it can lay dormant for decades before potentially causing a cancer, this occurs mostly in a non-smoking population composed of males four to one over females.

If you have never had an oral cancer examination, there is no better time to schedule one than during Oral Cancer Awareness Month in April. When you do, be sure to ask that this examination be made a routine part of all of your future dental check-ups. For a list of local dental professionals who are participating in this year's event by offering free oral cancer screenings, visit the Oral Cancer Foundation's website.

For more information about oral cancer and its diagnosis and treatment, visit the websites of the organizations listed below.

About Oral Cancer Awareness Month

Each April, several of the nation's top dental associations join together with the Oral Cancer Foundation to raise awareness for oral and oropharyngeal cancers. Many dental professionals around the country open their offices to do free screenings to the public during this month each year as well. This is an important reminder to the public that when these cancers are detected and treated early, mortality and treatment related health problems are reduced. For more information visit the Oral Cancer Foundation website at www.oralcancer.org.

1. SEER – National Vital Statistics Reports 







Nobel Biocare launched creos syntoprotect

Posted on March 25, 2021

creosTM syntoprotect joins xenoprotect, allo.gain, allo.protect, xenogain and wound dressing to establish Nobel Biocare as the supplier of choice for natural or synthetic regeneration need.

Nobel Biocare has partnered with the synthetic membrane market leader and launched creos™ syntoprotect, a new line of dense PTFE membranes, expanding its portfolio of regenerative products. Watch the full video here.

Nobel Biocare has partnered with the synthetic membrane market leader and launched a new line of dense PTFE membranes, expanding its portfolio of regenerative products. The move allows Nobel Biocare and its family of carefully-designed regeneration solutions – creos – to take a decisive step towards meeting the ever-diverse needs of dental professionals.

The creos™ syntoprotect dense PTFE membranes are designed to withstand exposure to the oral cavity for extraction socket management when primary closure is not possible. The line also offers 13 shapes of titanium-reinforced dense PTFE membranes for ridge augmentations and grafting large osseous defects.

By launching syntoprotect, Nobel Biocare is bringing to market a new solution that is based on an established technology with more than 25 years of clinical practice.

“With syntoprotect we aim to provide our customers with the confidence and peace of mind they are looking for.” said Philip Schulze-Smidt, VP / GM Regenerative Solutions, Business Development & Strategy. “The result is a line of synthetic solutions that promises to bring proven predictability1,2 and efficacy3,4,5 to tissue and bone regeneration, while introducing attractive design features.”

Finally, the 13 titanium-reinforced membrane options are easy to trim and versatile in shaping and positioning.

“Every patient is different: we know it and our customers know it. creos™ syntoprotect marks a turning point for our creos line, complementing our barrier membrane offering so we can provide dental professionals with natural and synthetic solutions for different indications, from a source they can trust,” added Philip Schulze-Smidt.

creos™ syntoprotect is now available in Europe and United States, where the line of creos regenerative products is conveniently available from the Nobel Biocare online store or through any Nobel Biocare Sales Representative.

creos™ syntoprotect will become available in additional geographies in the coming months.

For more information on creos™ and the new creos™ syntoprotect, dental professionals can visit nobelbiocare.com/creos or contact their local Sales Representative.

References

1. Barboza EP, Stutz B, Ferreira VF, Carvalho W. Guided bone regeneration using nonexpanded polytetrafluoroethylene membranes in preparation for dental implant placements - a report of 420 cases. Implant Dent. 2010;19:2-7.

2. Hoffman O, Bartee BK, Beaumont C, Kasaj A, Deli G, Zafiropoulos GG. Alveolar bone preservation in extraction sockets using non-resorbable dense PTFE membranes: A retrospective non-randomized study. J Periodontol 2008;79:1355-1369.

3. Fotek PD, Neiva RF, Wang HL. Comparison of dermal matrix and polytetrafluoroethylene membrane for socket bone augmentation: a clinical and histologic study. J Periodontol 2009;80:776-785.

4. Barboza EP, Francisco BS, Ferreira VF. Soft tissue enhancement using non-expanded PTFE membranes without primary closure [abstract]. Presented at the 2008 Research Forum Poster Session. Annual Meeting of the American Academy of Periodontology (AAP) in Seattle, WA, September 6-9, 2008.

5. Ronda M, Rebaudi A, Torelli L, Stacchi C. Expanded vs. dense polytetrafluoroethylene membranes in vertical ridge augmentation around dental implants: a prospective randomized controlled clinical trial. Clin. Oral Impl. Res. 2014 Jul;25(7):859-66. 







America's ToothFairy Teams Up with Crest and Oral-B to Help Kids Conquer Cavities 2Gether

Posted on March 24, 2021

There is nothing more precious than a child’s smile. However, according to the American Academy of Pediatric Dentistry, nearly half of children aged 6-11 are affected by tooth decay. While largely preventable, tooth decay is exacerbated with children in underserved communities, who are twice as likely to suffer from this condition, and their dental diseases are more than twice as likely to go untreated. It can also lead to missed school, trouble eating, sleeping and heightened risk of infection.¹

With a commitment of healthier smiles for all, Crest and Oral-B Kids are teaming up with actor, Miles Brown on a new Conquer Cavities 2Gether initiative. Conquer Cavities 2Gether encourages kids and parents to take the pledge to brush for two minutes, twice a day with a fluoride toothpaste. For every pledge, Crest and Oral-B Kids will donate up to 10,000 Conquer Cavities kits, including toothpaste, toothbrushes and educational materials, to children and families in need.

“Growing up in front of the camera, my parents instilled in me the importance of a healthy smile,” said Brown, “That’s why I’m excited to partner with Crest and Oral-B Kids to inspire and encourage kids and parents to take the pledge, so they can put their best smile forward – no matter where their journey takes them.”

Crest and Oral-B Kids are also proud to partner with America’s ToothFairy, a nonprofit resource provider that has helped nonprofit dental clinics provide dental care to more than 8 million children nationwide. Through our partnership, we will distribute Conquer Cavities 2Gether kits to five partner dental clinics in underserved communities around the country.

“We know there are millions of kids in the U.S. with restricted access to dental care and some even lack basic items like their own toothbrush,” said Jill Malmgren, Executive Director, America’s ToothFairy, “We’re thrilled to collaborate with Crest and Oral-B Kids to get Conquer Cavities 2Gether kits to the kids and families that need them most.”

This campaign is part of the Crest and Oral-B aspiration to enable 100% of Americans to have access to oral care products, oral health education and dental care. In 2020 alone, Crest and Oral-B donated more than $2.5 million in products and care to support healthy smiles across the country. The brands have also provided more than $140 million in continuing education to dental professionals over the past 10 years and offered educational materials that make it easy for dental professionals, parents and teachers to educate their kids about the importance of oral care.

“A smile is priceless, and every kid deserves to grow up with a happy and healthy one,” said Carlos Quintero, Vice President, North America Oral Care, P&G “Especially knowing the connection between oral health and whole body health, we are committed to taking action to ensure every child is free and proud to show off their smile to the world. Just one pledge can provide a family with oral care product and education to help build healthy oral habits to last a lifetime.”

To learn more about the Conquer Cavities 2Gether program, and take the pledge to brush for two minutes, twice a day visit ConquerCavities2Gether.com.

1. American Academy of Pediatric Dentistry- Pediatric Oral Health Research and Policy Center: State of Little Teeth Report. 2nd ed. 2019.

About Crest

A trusted leader in oral health, Crest was the first oral care brand to secure the ADA Seal of Acceptance for a clinically proven fluoride toothpaste. Since first introducing fluoride toothpaste 65 years ago, it is estimated that Crest has helped prevent countless cavities in the United States.

About Oral-B

Oral-B is the worldwide leader in the over $5 billion brushing market. Part of the Procter & Gamble Company, the brand includes manual and electric toothbrushes for children and adults, oral irrigators and interdental products, such as dental floss.

About Procter & Gamble

P&G serves consumers around the world with one of the strongest portfolios of trusted, quality, leadership brands, including Always, Ambi Pur, Ariel, Bounty, Charmin, Crest, Dawn, Downy, Fairy, Febreze, Gain, Gillette, Head & Shoulders, Lenor, Olay, Oral-B, Pampers, Pantene, SKII, Tide, Vicks, and Whisper. The P&G community includes operations in approximately 70 countries worldwide. Please visit https://www.pg.com for the latest news and information about P&G and its brands.

About America’s ToothFairy: National Children’s Oral Health Foundation

As a resource provider, America’s ToothFairy increases access to oral health care by supporting nonprofit clinics and community partners delivering education, prevention and treatment services for underserved children. Since its inception in 2006, America’s ToothFairy has distributed more than $22 million in donated products, educational materials and financial grants to improve oral health outcomes for children and youth in need. For more information, visit ToothFairy.org.  







Medicaid expansion made many mouths healthier, study finds

Posted on March 24, 2021

As the pandemic’s economic effects drive more people to enroll in Medicaid as safety-net health insurance, a new study suggests that the program’s dental coverage can improve their oral health in ways that help them seek a new job or do better at the one they have.

The study focuses on the impact of dental coverage offered through Michigan’s Medicaid expansion, called the Healthy Michigan Plan. The researchers, from the University of Michigan, used a survey and interviews to assess the impact of this coverage on the health and lives of low-income people who enrolled.

In all, 60% of the 4,090 enrollees surveyed for the new study had visited a dentist at least once since enrolling in the Healthy Michigan Plan a year or two earlier, which the researchers verified with state records.

Among those who saw a dentist in that time, 57% said their oral health had improved since enrolling. The percentage who reported better oral health was even higher among Black respondents and those who said they’d been uninsured for a year or more before getting covered.

The findings are published in the Journal of Public Health Dentistry by a team from the U-M Institute for Healthcare Policy and Innovation that evaluates the impacts of the Healthy Michigan Plan. The authors hope their findings will inform policy decisions about dental coverage for Medicaid plans in Michigan and other states.

Impact on work lives

Half of the respondents had jobs or were self-employed, though their incomes were low enough to qualify for the Healthy Michigan Plan – about $15,600 for an individual in the year studied.

Just over 39% of all survey respondents, with jobs or without, said their oral health had improved since they enrolled.

Of those who had jobs and reported improved oral health, 76% said that their Healthy Michigan Plan coverage had helped them do a better job at work compared to 65% of those who had jobs but hadn’t experienced improvements in oral health.

Meanwhile, 60% of the unemployed people who said their oral health had improved credited their coverage with helping them look for a job, compared with 51% of those who hadn’t experienced improvement in oral health.

Although the data were collected before the COVID-19 pandemic began, the findings have implications for the hundreds of thousands of Michiganders who have enrolled in the Healthy Michigan Plan in the past year when they lost jobs or income.

The Healthy Michigan Plan includes basic dental care coverage such as cleanings, fillings, X-rays and dentures, and is open to people making up to 133% of the federal poverty level. Enrollment has grown to more than 895,000.

Voices of Healthy Michigan Plan enrollees

Most respondents had no health insurance coverage in the year before enrolling in Michigan’s program.

“The Healthy Michigan Plan’s dental coverage enabled many to get the dental care they needed,” says Edie Kieffer, Ph.D., M.P.H., lead author of the paper and a professor emeritus in the U-M School of Social Work. “In our interviews with enrollees, people talked about the great impact of having this dental coverage. People told us that, without dental coverage, they had to have their teeth pulled. They used their new coverage to get dentures, which improved their appearance, employment options and ability to eat. Dental coverage helped people address dental infections and get preventive dental care.”

Some enrollees mentioned that previously they had turned to hospital emergency departments for urgent dental care needs, for instance to get an antibiotic to treat an oral infection, but not to address the underlying problem that led to the infection. One interviewee said their first dental visit uncovered a tumor.

As one of the middle-aged male participants interviewed by the researchers and quoted in the paper says:

My teeth were pretty bad…and they fixed it up fine, and now…I feel better when I am looking for a job…I feel better because my appearance has changed a lot. That has helped me a lot, physically and mentally.

Practice and policy implications

The authors note that Medicaid coverage in Michigan improves patients’ access to primary health care as well as basic dental care. In both settings, providers can identify patients at risk of oral health problems, and suggest treatments for problems so they can be addressed before they worsen.

Nearly half of all survey respondents said their access to dental care had improved thanks to their dental coverage. That percentage was even higher among the 60% of respondents who had been uninsured for at least a year before getting covered under the Healthy Michigan Plan.

The findings about Michigan Medicaid expansion coverage’s impact on dental health are similar to other findings on health outcomes made by the IHPI team, says John Z. Ayanian, M.D., M.P.P., the study’s senior author.

“We can clearly see the positive impact of Medicaid coverage of dental care,” he says. “These findings have implications for states that have yet to expand Medicaid at all, or to include dental coverage in their Medicaid expansion programs.”

Ayanian heads the IHPI team that is evaluating the Healthy Michigan Plan through a collaboration with the Michigan Department of Health and Human Services. He also serves as IHPI’s director and a primary care physician and professor of internal medicine at Michigan Medicine, U-M’s academic medical center.

Access to dental care for Medicaid enrollees depends not just on the availability of coverage, which can vary by state, but also on the number of dental practices that accept Medicaid plans. Low reimbursement rates are a major factor in Michigan, says Romesh Nalliah, D.D.S., M.H.C.M., a co-author of the paper and professor at the U-M School of Dentistry.

Dental disparities

Nalliah notes that the inclusion of adult dental coverage in Medicaid and other plans could help reduce the disparities in oral health that he and others have documented.

In 2019, he and colleagues published data showing that while the oral health gap between Black and white Americans had narrowed between 1999 and 2014 (the year before Medicaid expansion took effect under the Affordable Care Act), there were still disparities in dental visits and tooth loss due to cavities and gum disease. More than 22% of Black Americans over age 65 had lost all their natural teeth by 2014, compared with 14% of whites.

The National Poll on Healthy Aging, also based at IHPI, has also studied dental health among adults aged 50 to 64 and adults over 65, finding disparities by income, race/ethnicity and education level in both age groups.

Oral health has important influences on people’s overall health, Kieffer explains, and poor oral health is very common among low-income adults.

Because dental coverage is an optional benefit under state Medicaid and Medicaid expansion plans, she and her colleagues hope policymakers will consider the potential for Medicaid dental coverage to both reduce oral health disparities, and improve the health and socioeconomic well-being of low-income adults.

In addition to Kieffer, Ayanian and Nalliah, the study’s authors include Susan D. Goold, M.D., M.H.S.A., M.A., Tom Buchmueller, Ph.D., Erin Beathard, M.P.H., M.S.W., Matthias A. Kirch, M.S., Erica Solway, Ph.D., M.P.H., M.S.W., Renuka Tipirneni, M.D., M.Sc., Sarah J. Clark, M.P.H., Adrianne N. Haggins, M.D., M.Sc., and Minal R. Patel, Ph.D., M.P.H. 







Colgate® Announces Recipients of the Colgate Award for Research Excellence (CARE)

Posted on March 23, 2021

Colgate is pleased to announce this year’s recipients of the Colgate Award for Research Excellence (CARE). The CARE Program recognizes a new generation of academic researchers by providing up to $30,000 USD (per project) to support oral health research projects across multiple disciplines.

The five junior faculty members chosen to receive this year’s awards are:

Adriana Manso, DDS, MSc, PhD -- University of British Columbia, Faculty of Dentistry “Novel multifunctional curcumin-based adhesive varnish for caries control”

Ammaar Abidi, DDS, PhD -- University of Tennessee, Health Science Center, College of Dentistry “Evaluation Of The Effects Of Phytocannabinoids On Human Gingival Fibroblast Proliferation, Migration, Growth and Inflammatory Cytokine Production”

Bianca Dearing, DDS, MPhil, PhD -- Meharry Medical College, School of Dentistry “The Nashville KROHL Study: Oral Health Literacy in Underserved Mothers”

Yuan Liu, DDS, MS, PhD -- University of Pennsylvania, Penn Dental Medicine “Oral Candida infection in Infancy and Early Childhood Caries”

Zaher Jabbour, DMD, MSc, PhD -- University of California at LA, School of Dentistry “Does therapeutic silver remain in carious lesions treated with silver diamine fluoride and potassium iodide? And does it affect the bonding strength of restorative materials?”

Proposals were reviewed by an independent, esteemed group of senior academic dental researchers. Winners were selected based on program criteria, which included innovation, clinical significance, originality, and scientific quality. CARE grants are typically offered for periods of 12 months.

“The CARE Program fosters the development of junior faculty by providing seed research funding to emerging leaders in academia at a time in their career path when it is most needed,” said Maria Ryan, Vice President and Chief Dental Officer, Global Technology at Colgate. “Every year, we look forward to meeting and supporting talented researchers in the early stages of their careers. We are pleased to fund innovative projects that promise to advance industry knowledge and perhaps even revolutionize the field of dentistry. On behalf of Colgate, sincere congratulations to the winners of this year’s grant awards.”

Established in 2016, the Colgate CARE Program is designed to foster and provide financial support to young academic researchers. In order to be eligible for the Colgate CARE grant, faculty applicants must be in the first five years of an academic appointment.

For more information about the Colgate CARE Program for Young Academic Researchers and application guidelines, or visit https://www.colgateprofessional.com/care-program (USA) or www.colgateprofessional.ca/en-ca/care-program (Canada).

ABOUT COLGATE-PALMOLIVE

Colgate-Palmolive Company is a caring, innovative growth company reimagining a healthier future for all people, their pets, and our planet. Focused on Oral Care, Personal Care, Home Care and Pet Nutrition, the Company sells its products in more than 200 countries and territories under brands, such as Colgate, Palmolive, elmex, hello, meridol, Sorriso, Tom’s of Maine, EltaMD, Filorga, Irish Spring, PCA Skin, Protex, Sanex, Softsoap, Speed Stick, Ajax, Axion, Fabuloso, Soupline and Suavitel, as well as Hill’s Science Diet and Hill’s Prescription Diet. The Company is recognized for its leadership and innovation in promoting environmental sustainability and community well-being, including its achievements in saving water, reducing waste, promoting recyclability, and improving children’s oral health through its Bright Smiles, Bright Futures program, which has reached more than one billion children since 1991. For more information about Colgate’s global business and how the Company is building a future to smile about, visit www.colgatepalmolive.com.







AO congratulates 2021 Best Presentation Research Award Winners

Posted on March 22, 2021

With more than 160 abstracts and e-posters submitted for the Academy of Osseointegration’s (AO) 2021 Virtual Annual Meeting, attendees were provided a first-hand look at the wealth of original and groundbreaking research.

Six researchers have been recognized by a committee of their peers in a variety of best presentation awards for clinical and scientific research. The winners are:

Best Oral Clinical Presentation

Pietro Felice, MD, DDS

4mm Supershort Implants Compared with Longer Implants Placed in Reconstructed Posterior Atrophic Jaws: 3 Year Results from an RCT

Best Oral Scientific Presentation

Gülce Çakmak, DDS, PhD

Accuracy of Different Complete-arch Digital Scanning Techniques, Using a Combined Healing Abutment-scan Body System

First Place E-poster Award

Ping Wang, DMD

P119 – Effect of Connective Tissue Graft on Buccal Bone Dimension and Esthetics Following Immediate Implant Placement

Second Place E-poster Award

Alexandra Stuart-Smith, MSc

P106 – Angulated Screw Channel Solution With Increased Preload

Best Case Presentation

Buddhapoom Wangsrimongkol, DDS

P122 – New Implant Abutment Design for Vertical Orthodontic Movement: A Case Report

Best Clinical Innovations

Rafael Siqueira, DDS, MS, PhD

Comprehensive Peri-implant Tissue Evaluation With Ultrasonography and Cone-Beam Computed Tomography

All lectures were assessed on the following criteria: originality or innovativeness; significance on implant dentistry; appropriate method of analysis; relevance of conclusions; and overall quality of presentation.

Attendees of the 2021 Virtual Annual Meeting can view the full research presentations via the meeting platform. Additionally, the entire collection of 2021 E-posters is immediately available for viewing on the Academy's website.

Watch in June for the opening of the 2022 Call for Abstracts to be held in conjunction with the Academy's 37th Annual Meeting, February 24 – 26, 2022 in San Diego, CA.

About Academy of Osseointegration

With approximately 4,000 members in more than 70 countries, AO is recognized as the premier international association for scientists and professionals interested in osseointegration and implant dentistry. AO serves as a nexus where specialists, generalists and scientists can come together to evaluate emerging research, technology, and techniques; share best practices; and define optimal patient care using timely science and evidence-based methods. Like us on Facebook, follow us on Twitter and Instagram @AcademyOsseo; @AcademyofOsseointegration on Linkedin; and subscribe to us on YouTube.

 







Formlabs Launches Scan to Model Feature

Posted on March 18, 2021

Formlabs, a leading 3D printing company, today announced Scan to Model, a new feature in its PreForm software, that is designed to convert intraoral scans into 3D printable models easily. Dental and orthodontic professionals can use Scan to Model as an entry point into digital workflows without having prior experience with digital dental design software. Creating diagnostic, formed appliance and fit check models is simple: users scan a patient's teeth with a 3D intraoral scanner, upload the raw model into PreForm's Scan to Model tool, and then print with a Formlabs Form 3B printer - the whole process completed in less than one hour.

The dental industry is rapidly evolving from manual processes to digital, though for many practices, this shift can be daunting. While more than 30% of orthodontists have an intraoral 3D scanner, only 4% have 3D printing capabilities at their practice, proving the desire to adopt the technology is apparent, though cost and training are large hurdles associated with fulfilling the need. Formlabs Dental, first launched as a dedicated Business Unit in November 2019, aims to make flexible and patient-specific treatment protocols accessible to every dental professional.

Sam Wainwright, Dental Products Manager of Formlabs, said: “Getting started in digital dentistry couldn’t be easier with the Formlabs Dental Ecosystem. The Scan to Model software feature does all the work, converting intraoral 3D scan files into printable dental models so it's simple for providers to bring digital model production in-house. This new software feature, our printers, and dental resins of the Formlabs Dental Ecosystem support dentistry’s transformation enabling both newcomers and experienced professionals to add digital workflows.”

Before Scan to Model, technicians that completed 3D scans of patients’ teeth using an intraoral scanner would have to be well-versed in complex dental CAD software, use open-source mesh editors not designed for the needs of dental professionals, or outsource this processing to a dental lab. Now, Scan to Model enables dentists to reduce:

-Effort required to turn a 3D intraoral scan into a simple printed model

-Overall turnaround time for models and retainers, enabling same-day delivery

-Number of software programs required to perform simple model preparation

"Scan to Model is more advanced than an open-source mesh editor and faster than going through a comprehensive dental design program. My staff and I started using it immediately with no issues. It's a great entry point for doctors who are interested in digital," said James E. Paschal, DMD, MS, a Formlabs Dental customer.

About Formlabs Dental

Formlabs is expanding access to digital fabrication, so anyone can make anything. The leading 3D printing company introduced its new dental business unit in November 2019 to uniquely meet the needs of dental labs and practices of all sizes. Formlabs Dental is made up of a team of dental professionals dedicated to providing the best 3D printing solutions in the industry. Formlabs has touched the lives of hundreds of thousands of patients, having printed 13 million dental parts on the Form 2, and expanding this impact even further with the recent additions of its dental-focused hardware devices, the Form 3B and Form 3BL. In addition to its hardware products, Formlabs has over 50 materials scientists and a robust offering of dental materials that are available to be used on the Form 3B and Form 3BL printer. 







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