Inside Dentistry
March 2016
Volume 12, Issue 3


Plaque is the traditional term that has been used to describe the soft material on the teeth and within the pockets. Today we recognize that plaque, now called biofilm, is a much more complex material that functions through coordination of bacteria within a protective slime. Many years of data and research has demonstrated that the oral biofilm causing periodontal disease has distant systemic affects and has been connected to numerous medical conditions. The health conditions examined here are not the only ones associated with periodontal disease. Evidence also links prostate disease, colon cancer, pancreatic cancer, and poor pregnancy outcomes (preterm birth and low birth weight) to periodontal disease to varying degrees; a full review of all conditions was beyond the scope of this article. Periodontal treatment is evolving to be a major component of full-body medical care and controlling the associated biofilm yields better overall systemic health.


Gregori M. Kurtzman, DDS, MAGD, DICOI, has no relevant conflicts of interest to disclose.

About the Author

Gregori M. Kurtzman, DDS, MAGD, DICOI
Private Practice
Silver Spring, Maryland


1. Loos BG. Systemic effects of periodontitis. Int J Dent Hyg. 2006;4(suppl 1):34-38; discussion 50-52.

2. Hojo K, Nagaoka S, Ohshima T, Maeda N. Bacterial interactions in dental biofilm development. J Dent Res. 2009;88(11):982-990.

3. Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nature Review. 1013(13):159-175.

4. White blood cell enzyme contributes to inflammation and obesity. Medical Xpress website. http://medicalxpress.com/news/2013-04-white-blood-cell-enzyme-contributes.html. April 2, 2013. Accessed January 7, 2016.

5. Herzberg MC, Weyer MW. Dental plaque, platelets, and cardiovascular diseases. Ann Periodontol. 1998;3(1):151-160.

6. Scannapieco FA. Position paper of The American Academy of Periodontology: periodontal disease as a potential risk factor for systemic diseases. J Periodontol. 1998;69(7):841-850.

7. Syrjänen J. Vascular diseases and oral infections. J Clin Periodontol. 1990;17(7 pt 2):497-500.

8. Valtonen VV. Infection as a risk factor for infarction and atherosclerosis. Ann Med. 1991;23(5):539-543.

9. Nomura R, Otsugu M, Naka S, et al. Contribution of the interaction of Streptococcus mutans serotype k strains with fibrinogen to the pathogenicity of infective endocarditis. Infect Immun. 2014;82(12):5223-5234.

10. Haraszthy VI, Zambon JJ, Trevisan M, et al. Identification of pathogens in atheromatous plaques [abstract 273]. Dent Res. 1998;77(spec. iss. B):666.

11. Deshpande RG, Khan MB, Genco CA. Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis. Infect Immun. 1998;66(11):5337-5343.

12. Dhadse P, Gattani D, Mishra R. The link between periodontal disease and cardiovascular disease: How far we have come in last two decades? J Indian Soc Periodontol. 2010;14(3):148-154.

13. Baker L. Poor oral health increases stroke risk, UB study finds. www.buffalo.edu/imsd/about-imsd/the-buffalo-niagara-region.host.html/content/shared/university/news/news-center-releases/2000/10/4917.detail.html. October 25, 2000. Accessed January 7, 2016.

14. Persson GR, Imfeld T.: Periodontitis and cardiovascular disease. Ther Umsch. 2008 Feb;65(2):121-6.

15. Desvarieux M, Demmer RT, Rundek T, et al. Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Circulation. 2005;111(5):576-582.

16. Beck JD, Eke P, Heiss G, et al. Periodontal disease and coronary heart disease: a reappraisal of the exposure. Circulation. 2005;112(1):19-24.

17. Joshipura KJ, Hung HC, Rimm EB, et al. Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke. 2003;34(1):47-52.

18. Chiu B. Multiple infections in carotid atherosclerotic plaques. Am Heart J. 1999;138(5 pt 2):S534-S536.

19. Loesche WJ, Schork A, Terpenning MS, et al. The relationship between dental disease and cerebral vascular accident in elderly United States veterans. Ann Periodontol. 1998;3(1):161-174.

20. Wu T, Trevisan M, Genco RJ, et al. Examination of the relation between periodontal health status and cardiovascular risk factors: serum total and high density lipoprotein cholesterol, C-reactive protein, and plasma fibrinogen. Am J Epidemiol. 2000;151(3):273-282.

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