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The GentleWave® System with CleanFlow™ Technology

There are challenges in root canal treatment that are beyond the reach of the most skilled hands. Uninstrumented spaces. Undetected canals. Multi-species biofilm. Patient pain and anxiety.

Adding the GentleWave® System with CleanFlow™ Technology augments your ability to meet these challenges with ease. The improved CleanFlow Procedure Instrument (PI) is now the only PI you need to treat premolars, molars and anterior teeth with the GentleWave Procedure.

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GentleWave G4 System

Beyond irrigation. Beyond clean.

See how the GentleWave System with CleanFlow Technology excels at debridement and disinfection.

GentleWave CleanFlow Video play

Designed to Go the Distance

The GentleWave System takes you beyond canal complexity that can hinder thorough disinfection and debridement.

It starts inside the console, where the irrigant is thoroughly degassed, precisely diluted and continuously refreshed. Next, it enters the sealed closed-loop delivery system, where the system’s physics-accelerated chemistry becomes truly remarkable.

Now the CleanFlow PI and Matrix have been further refined to enable more effective and efficient root canal treatment — on every tooth*.

Controlled Cavitation

As the irrigant reaches the head of the procedure instrument, it passes through a narrow orifice, creating a continuous cavitation cloud of tiny, imploding vapor bubbles.

Multisonic Activation

These implosions create a constant barrage of shockwaves able to physically and chemically disrupt and dissolve pulp, biofilm and other organic and inorganic debris. This is the multsonic energy of the GentleWave System.

Thorough Disinfection

The multisonic energy vibrates throughout the root system unhindered, including fine anatomy, and accelerates the chemistry of the irrigant. This dramatically speeds up debridement1 and disinfection.

Apical Protection

Simultaneously, as the irrigant stream passes over the root canal system opening, vortical flow is created. True to physics, this produces a negative pressure environment2 which guards against apical extrusion.

Refreshed Irrigation

The vortical flow creates tornado-like spirals which descend then rise, lifting debris up and out of the canal, and allowing irrigant to be continuously refreshed.

*The GentleWave Procedure is not indicated for third molars.

Proof Positive

A body of clinical research. And over 1 million real-world procedures completed...and counting!

Clean Beyond Compare

Predictably removes up to 99.9% of biofilm3

Cleans up to 98.1% of organic tissue in mesial canals4

Effectively disinfects and debrides uninstrumented, undetected and intricate anatomies4,5

Apical Efficacy, Achieved

4X - 8.5X greater penetration into dentinal tubules vs. ulstrasonic systems6

Superior debridement in the apical third of mesial conals4

Unsurpassed cleaning in apical-thirds7,8

Safety by Design

Negative apical pressure across apical sizes and canal types2,9

Not associated with extrusion in curved and straight distal canals10

Designed for Procedural Ease

The Ultimate Root Canal Technology

A procedure instrument and matrix system custom-designed for your high-precision needs.

The CleanFlow Procedure Instrument and Matrix System

One Procedure Instrument

Optimized for improved procedure fluid replenishment with an expanded indication to include anterior teeth

One Matrix

Enhanced to interlock with precision for a lasting seal and shape the platform to center over the tooth access

Every Tooth*

The evolution of CleanFlow Technology makes treating every tooth* possible with the CleanFlow PI and Matrix system

* The GentleWave Procedure is not indicated for third molars.

“I’ve been using the enhanced CleanFlow Procedure Instrument exclusively for all case types, including anterior teeth, for several months. I can confidently say it’s a win for GentleWave System practitioners and their patients.”

Dr. James A. Smith, Jr., of Advanced Endodontics

Designed for the Patient Experience

Every case is another opportunity to lessen the stress around root canal treatment—both during and afterwards—and help drive referrals.

Positive Treatment Outcomes

Little to no post-treatment pain

96.6% of patients report mild to no pain within 48 hours11

Rapid rates of healing

97.7% 12-month healing rate12

Positive Treatment Experience

Single-handed cleaning and disinfection

The procedure instrument enables one-handed procedures for greater comfort

Minimal noise

The system’s multisonic frequencies are audible as white noise

1. Haapasalo M, Wang Z, Shen Y, Curtis A, Patel P, Khakpour M. Tissue dissolution by a novel multisonic ultracleaning system and sodium hypochlorite. J Endod. 2014;40:1178–1181

2. Haapasalo M, Shen Y, Wang Z, Park E, Curtis A, Patel P, Vandrangi P. Apical pressure created during irrigation with the GentleWaveTM system compared to conventional syringe irrigation. Clin Oral Investig. 2016 Sep;20(7):1525-34. doi: 10.1007/s00784-015-1632-z. Epub 2015 Oct 26. PMID: 26498770.

3. Zhang D, Shen Y, de la Fuente-Núñez C, Haapasalo M. In vitro evaluation by quantitative real-time PCR and culturing of the effectiveness of disinfection of multispecies biofilms in root canals by two irrigation systems. Clin Oral Investig. 2019 Feb;23(2):913-920. doi: 10.1007/s00784-018-2515-x. Epub 2018 Jun 15. PMID: 29948281.

4. Molina B, Glickman G, Vandrangi P, Khakpour M. Evaluation of Root Canal Debridement of Human Molars Using the GentleWave System. J Endod. 2015 Oct;41(10):1701-5. doi: 10.1016/j.joen.2015.06.018. Epub 2015 Aug 12. PMID: 26275599.

5. Wang Z, Shen Y, Haapasalo M. Root Canal Wall Dentin Structure in Uninstrumented but Cleaned Human Premolars: A Scanning Electron Microscopic Study. J Endod. 2018 May;44(5):842-848. doi: 10.1016/j.joen.2018.01.014. Epub 2018 Mar 15. PMID: 29550004.

6. Vandrangi P (2016) Evaluating Penetration Depth of Treatment Fluids into Dentinal Tubules Using the GentleWave® System. Dentistry 6: 366. doi:10.4172/2161-1122.1000366

7. Ma J, Shen Y, Yang Y, Gao Y, Wan P, Gan Y, Patel P, Curtis A, Khakpour M, Haapasalo M. In vitro study of calcium hydroxide removal from mandibular molar root canals. J Endod. 2015 Apr;41(4):553-8. doi: 10.1016/j.joen.2014.11.023. Epub 2015 Jan 14. PMID: 25596727.

8. Jaramillo DE, & Arriola AR. Histological Evaluation of Multisonic Technology for Debridement of Vital and Necrotic Pulp Tissues from Human Molar Teeth. An Observational Study. Appl. Sci. 2021; 11, 11002.

9. Chen B, Shen Y, Ma J, & Haapasalo M. Effect of apical size on apical pressure during syringe-needle and multisonic negative pressure irrigation. Odontology. 2021; 109: 625-631.

10. Charara K, Friedman S, Sherman A, Kishen A, Malkhassian G, Khakpour M, Basrani B. Assessment of Apical Extrusion during Root Canal Irrigation with the Novel GentleWave System in a Simulated Apical Environment. J Endod. 2016 Jan;42(1):135-9.

11. Data on file. Sonendo, Inc.

12. Sigurdsson A, Garland RW, Le KT & Rassoulian SA. Healing of Periapical Lesions After Endodontic Treatment with the GentleWave Procedure: A Prospective Multicenter Clinical Study. Journal of Endodontics. 2018;44(3):510-517.

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